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Species Reactivity
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验证数据展示

  • IHC staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

    IHC staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 13416-1-AP (GPR17 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13416-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

    IF Staining of mouse cerebellum using 13416-1-AP (same clone as 13416-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using GPR17 antibody (13416-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13416-1-PBS in a different storage buffer formulation.

GPR17 Polyclonal antibody, PBS Only

GPR17 Polyclonal Antibody for IHC, IF-P, Indirect ELISA
Cat No. 13416-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IF-P, Indirect ELISA

别名

UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

13416-1-PBS targets GPR17 in IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IF-P, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 GPR17 fusion protein Ag4106 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 G protein-coupled receptor 17
别名 UDP/CysLT receptor, R12, P2Y-like receptor, P2Y like receptor, G-protein coupled receptor 17
计算分子量 367 aa, 41 kDa
观测分子量 50 kDa
GenBank蛋白编号BC031653
基因名称 GPR17
Gene ID (NCBI) 2840
RRIDAB_2279341
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ13304
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GPR17 is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, particularly in the central nervous system (CNS). GPR17 is considered a modulator of CNS myelination and is involved in reconstructing and repairing demyelinating plaques caused by ongoing inflammatory processes, such as in multiple sclerosis (MS). It is present in nerve cells and precursor oligodendrocyte cells, playing a role in the differentiation and maturation of oligodendrocytes (PMID: 32182666). GPR17 is a multifaceted GPCR with implications in immune regulation, glucose metabolism, neurodegenerative diseases, and potentially in treating anxiety disorders.