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GUCY2C Monoclonal antibody, PBS Only

GUCY2C Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1F5F6

Cat no : 67782-1-PBS

Print datasheet

Synonyms

GC C, Guanylyl cyclase C, GUC2C, GUCY2C, hSTAR, Intestinal guanylate cyclase, STA receptor, STAR

验证数据展示

  • WB analysis of Caco-2 using 67782-1-Ig (same clone as 67782-1-PBS)

    WB analysis of Caco-2 using 67782-1-Ig (same clone as 67782-1-PBS)

    Caco-2 cells were subjected to SDS PAGE followed by western blot with 67782-1-Ig (GUCY2C antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67782-1-PBS in a different storage buffer formulation.

产品信息

67782-1-PBS targets GUCY2C in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen GUCY2C fusion protein Ag19256 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name guanylate cyclase 2C (heat stable enterotoxin receptor)
Synonyms GC C, Guanylyl cyclase C, GUC2C, GUCY2C, hSTAR, Intestinal guanylate cyclase, STA receptor, STAR
Calculated Molecular Weight 1073 aa, 123 kDa
Observed Molecular Weight130 kDa
GenBank Accession NumberBC136544
Gene Symbol GUCY2C
Gene ID (NCBI) 2984
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP25092
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

GUCY2C is also named as GUC2C, STAR(Heat-stable enterotoxin receptor), Guanylyl cyclase C and belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the E.coli heat-stable enterotoxin and considered to be the true apical membrane receptor for the endogenous ligands uroguanylin and guanylin. GUCY2C is not present in the endocrine pancreas, but is localized exclusively to the ductal system which fully corresponds to the GUCY2C activity detected in the exocrine ductal system, but particularly not in islets of Langerhans. GUCY2C with a molecular mass of 130 kDa is detected in pancreatic and intestinal extracts.(PMID:11431160). The full length protein is 123 kDa and has a signal peptide and nine glycosylation sites.