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验证数据展示

  • WB analysis of NK-92 using 84583-4-RR (same clone as 84583-4-PBS)

    WB analysis of NK-92 using 84583-4-RR (same clone as 84583-4-PBS)

    NK-92 cells were subjected to SDS PAGE followed by western blot with 84583-4-RR (GZMA antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84583-4-PBS in a different storage buffer formulation.

Granzyme A Recombinant antibody, PBS Only

Granzyme A Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 84583-4-PBS

产品说明书

CloneNo. 241979E3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

GrA, GZMA, Fragmentin 1, EC:3.4.21.78, Cytotoxic T-lymphocyte proteinase 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

84583-4-PBS targets Granzyme A in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 Granzyme A fusion protein Ag1818 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
别名 GrA, GZMA, Fragmentin 1, EC:3.4.21.78, Cytotoxic T-lymphocyte proteinase 1
计算分子量 29 kDa
观测分子量27-30 kDa
GenBank蛋白编号BC015739
基因名称 Granzyme A
Gene ID (NCBI) 3001
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP12544
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Granzyme A(GrA, a tryptase) is necessary for target cell lysis in cell-mediated immune responses. It activates mitochondrial outer membrane permeabilization- and caspase-independent cell death pathways by cleaving the mitochondrial complex I component NDUFS3after lys56. Among serine proteases GrA has an unique quaternary structure consisting of a disulphide-linked homodimer of 60kDa linked via Cys93.(PMID: 12819769) This protein has 2 isoforms produced by alternative promoter usage with the MW of 29 and 27 kDa.