验证数据展示
产品信息
13830-1-PBS targets HTR7 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | HTR7 fusion protein Ag4742 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) |
Synonyms | |
Calculated Molecular Weight | 445 aa, 49 kDa |
Observed Molecular Weight | 50-55 kDa |
GenBank Accession Number | BC047526 |
Gene Symbol | HTR7 |
Gene ID (NCBI) | 3363 |
RRID | AB_2122706 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | P34969 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Serotonin (5-hydroxytryptamine; 5-HT) acts as a neurotransmitter and neuromodulator in the central nervous system(CNS) (PMID:23100172). The behavioral effects of 5-HT are mediated by a large family of specific 5-HT receptors. HTR7 (5-hydroxytryptamine receptor 7) is a G protein-coupled receptor (GPCR), and many transcription factors can bind to its promoter, such as AP2, EGR-1, and MAZ (PMID:34164474). It is located in different brain regions, such as the hypothalamus, thalamus, cerebral cortex, and hippocampus (PMID:29637287). HTR7 is associated with circadian rhythm, anxiety, depression, schizophrenia, nociception, and memory (PMID:9154233).