验证数据展示
产品信息
67168-1-PBS targets HUS1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | HUS1 fusion protein Ag28527 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | HUS1 checkpoint homolog (S. pombe) |
Synonyms | Checkpoint protein HUS1, hHUS1, HUS1 |
Calculated Molecular Weight | 32 kDa |
Observed Molecular Weight | 32 kDa |
GenBank Accession Number | BC007013 |
Gene Symbol | HUS1 |
Gene ID (NCBI) | 3364 |
RRID | AB_2882464 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
UNIPROT ID | O60921 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Hus1 belongs to the Rad family, form a heterotrimeric clamp with Rad1and Rad9 that acts as a putative sensor for DNA damage. This complex plays an apical role in the DNA damage response, loss of a functional complex affects many downstream checkpoint pathways [PMID: 11340080]. It is also a key complex involved in the activation of the ATR pathway. 9-1-1 forms a ring-shaped heterotrimer, resembling the homotrimeric sliding clamp, proliferating cell nuclear antigen (PCNA) [PMID: 19535328].