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HUS1 Monoclonal antibody, PBS Only

HUS1 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E8E9

Cat no : 67168-1-PBS

Print datasheet

Synonyms

Checkpoint protein HUS1, hHUS1, HUS1

验证数据展示

  • WB analysis using 67168-1-Ig (same clone as 67168-1-PBS)

    WB analysis using 67168-1-Ig (same clone as 67168-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67168-1-Ig (HUS1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67168-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 67168-1-Ig (same clone as 67168-1-PBS)

    IHC staining of human prostate cancer using 67168-1-Ig (same clone as 67168-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 67168-1-Ig (HUS1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67168-1-PBS in a different storage buffer formulation.

产品信息

67168-1-PBS targets HUS1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen HUS1 fusion protein Ag28527 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name HUS1 checkpoint homolog (S. pombe)
Synonyms Checkpoint protein HUS1, hHUS1, HUS1
Calculated Molecular Weight 32 kDa
Observed Molecular Weight 32 kDa
GenBank Accession NumberBC007013
Gene Symbol HUS1
Gene ID (NCBI) 3364
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO60921
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Hus1 belongs to the Rad family, form a heterotrimeric clamp with Rad1and Rad9 that acts as a putative sensor for DNA damage. This complex plays an apical role in the DNA damage response, loss of a functional complex affects many downstream checkpoint pathways [PMID: 11340080]. It is also a key complex involved in the activation of the ATR pathway. 9-1-1 forms a ring-shaped heterotrimer, resembling the homotrimeric sliding clamp, proliferating cell nuclear antigen (PCNA) [PMID: 19535328].