验证数据展示
产品信息
67168-1-PBS targets HUS1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | Human |
免疫原 | HUS1 fusion protein Ag28527 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | HUS1 checkpoint homolog (S. pombe) |
别名 | Checkpoint protein HUS1, hHUS1, HUS1 |
计算分子量 | 32 kDa |
观测分子量 | 32 kDa |
GenBank蛋白编号 | BC007013 |
基因名称 | HUS1 |
Gene ID (NCBI) | 3364 |
RRID | AB_2882464 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | O60921 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Hus1 belongs to the Rad family, form a heterotrimeric clamp with Rad1and Rad9 that acts as a putative sensor for DNA damage. This complex plays an apical role in the DNA damage response, loss of a functional complex affects many downstream checkpoint pathways [PMID: 11340080]. It is also a key complex involved in the activation of the ATR pathway. 9-1-1 forms a ring-shaped heterotrimer, resembling the homotrimeric sliding clamp, proliferating cell nuclear antigen (PCNA) [PMID: 19535328].