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验证数据展示

  • WB analysis using 67003-1-Ig (same clone as 67003-1-PBS)

    WB analysis using 67003-1-Ig (same clone as 67003-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67003-1-Ig (ICOSLG antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67003-1-PBS in a different storage buffer formulation.

ICOSLG/B7-H2/CD275 Monoclonal antibody, PBS Only

ICOSLG/B7-H2/CD275 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67003-1-PBS

产品说明书

CloneNo. 2G1F8

宿主/亚型

Mouse / IgG2a

种属反应性

Human

应用

WB, Indirect ELISA

别名

B7H2, ICOSLG, B7RP1, B7-related protein 1, B7-like protein Gl50

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67003-1-PBS targets ICOSLG/B7-H2/CD275 in WB, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human
免疫原 ICOSLG/B7-H2/CD275 fusion protein Ag6799 种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 inducible T-cell co-stimulator ligand
别名 B7H2, ICOSLG, B7RP1, B7-related protein 1, B7-like protein Gl50
计算分子量 33 kDa, 34 kDa
观测分子量 60-65 kDa, 28-35 kDa
GenBank蛋白编号BC064637
基因名称 ICOSLG
Gene ID (NCBI) 23308
RRIDAB_2882320
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO75144
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ICOSLG, also known as B7H2 or GL50, is a type I transmembrane glycoprotein belonging to the B7 ligand family. ICOSLG is extensively expressed on professional antigen-presenting cells including B cells, macrophages, and dendritic cells, as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells (PMID: 33756276; 35800767). It is a specific ligand for the T-cell-specific cell surface receptor ICOS and acts as a co-stimulatory molecule (PMID: 11023515; 11007762). The interaction of ICOSLG and ICOS plays important roles in the activation, proliferation, differentiation, and cytokine production of T cells as well as in the antibody secretion from B cells during secondary immune responses (PMID: 21851236).