验证数据展示
产品信息
67003-1-PBS targets ICOSLG/B7-H2/CD275 in WB, Indirect ELISA applications and shows reactivity with Human samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human |
| Immunogen | ICOSLG/B7-H2/CD275 fusion protein Ag6799 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | inducible T-cell co-stimulator ligand |
| Synonyms | B7H2, ICOSLG, B7RP1, B7-related protein 1, B7-like protein Gl50 |
| Calculated Molecular Weight | 33 kDa, 34 kDa |
| Observed Molecular Weight | 60-65 kDa, 28-35 kDa |
| GenBank Accession Number | BC064637 |
| Gene Symbol | ICOSLG |
| Gene ID (NCBI) | 23308 |
| RRID | AB_2882320 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O75144 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ICOSLG, also known as B7H2 or GL50, is a type I transmembrane glycoprotein belonging to the B7 ligand family. ICOSLG is extensively expressed on professional antigen-presenting cells including B cells, macrophages, and dendritic cells, as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells (PMID: 33756276; 35800767). It is a specific ligand for the T-cell-specific cell surface receptor ICOS and acts as a co-stimulatory molecule (PMID: 11023515; 11007762). The interaction of ICOSLG and ICOS plays important roles in the activation, proliferation, differentiation, and cytokine production of T cells as well as in the antibody secretion from B cells during secondary immune responses (PMID: 21851236).
