验证数据展示
产品信息
81176-1-PBS targets IDH1 in WB, IHC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IHC, FC (Intra), Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | IDH1 fusion protein Ag19749 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | isocitrate dehydrogenase 1 (NADP+), soluble |
别名 | IDH 1, IDH, IDCD, EC:1.1.1.42, Cytosolic NADP-isocitrate dehydrogenase |
计算分子量 | 414 aa, 47 kDa |
观测分子量 | 46 kDa |
GenBank蛋白编号 | BC012846 |
基因名称 | IDH1 |
Gene ID (NCBI) | 3417 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | O75874 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. It can form a homodimer(PMID:15173171). IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells(PMID:21079649 ).