IDH3B Monoclonal antibody, PBS Only
IDH3B Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse, Rat, Rabbit, Pig
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2D11A9
验证数据展示
产品信息
68199-1-PBS targets IDH3B in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat, Rabbit, Pig samples.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | Human, Mouse, Rat, Rabbit, Pig |
| Immunogen | IDH3B fusion protein Ag8693 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | isocitrate dehydrogenase 3 (NAD+) beta |
| Synonyms | FLJ11043, H IDHB, IDH3B, RP46 |
| Calculated Molecular Weight | 42 kDa |
| Observed Molecular Weight | 39-42 kDa |
| GenBank Accession Number | BC001960 |
| Gene Symbol | IDH3B |
| Gene ID (NCBI) | 3420 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | O43837 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Isocitrate dehydrogenase 3 (IDH3) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate and concurrently converts NAD+ into NADH. IDH3B(Isocitrate dehydrogenase 3 (NAD+) beta), also named as RP46, is the beta subunit of IDH3 and controls its substrate levels in the TCA cycle, and it is required for sperm mitochondrial metabolism and spermiogenesis (PMID: 18806796, PMID: 35985423). In addition, DH3B expression increased PFKFB3 protein levels and enhanced glucose uptake, and high expression of IDH3B correlated with poor survival in patients with ESCC, suggesting a potential application of IDH3B in prognosis (PMID: 31053633).