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  • Featured Product
  • KD/KO Validated

CoraLite®594-conjugated IFITM2 Polyclonal antibody

IFITM2 Polyclonal Antibody for

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

Conjugate

CoraLite®594 Fluorescent Dye

Cat no : CL594-12769

Print datasheet

Synonyms

Interferon-inducible protein 1-8D, Interferon-induced transmembrane protein 2, IFITM 2, DSPA2c, 18D

验证数据展示

Planning an IHC experiment? We recommend our IHCeasy IFITM2 Ready-To-Use IHC Kit. IFITM2 primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 12769-1-AP

产品信息

CL594-12769 targets IFITM2 in applications and shows reactivity with human samples.

Tested Applications Application Description
Tested Reactivity human
Immunogen IFITM2 fusion protein Ag3451 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name interferon induced transmembrane protein 2 (1-8D)
Synonyms Interferon-inducible protein 1-8D, Interferon-induced transmembrane protein 2, IFITM 2, DSPA2c, 18D
Calculated Molecular Weight 132 aa, 15 kDa
Observed Molecular Weight 15 kDa
GenBank Accession NumberBC009696
Gene Symbol IFITM2
Gene ID (NCBI) 10581
Conjugate CoraLite®594 Fluorescent Dye
Excitation/Emission Maxima Wavelengths588 nm / 604 nm
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ01629
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. Catalog#12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2.