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IFN-gamma R1 Monoclonal antibody, PBS Only

IFN-gamma R1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1H3A4

Cat no : 66704-1-PBS

Print datasheet

Synonyms

IFNGR1, IFN-gamma-R1, IFN-gamma receptor 1, IFN gamma receptor 1, IFN gamma R1

验证数据展示

  • WB analysis of HeLa using 66704-1-Ig (same clone as 66704-1-PBS)

    WB analysis of HeLa using 66704-1-Ig (same clone as 66704-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 66704-1-Ig (IFNGR1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66704-1-PBS in a different storage buffer formulation.

产品信息

66704-1-PBS targets IFN-gamma R1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen IFN-gamma R1 fusion protein Ag27085 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name interferon gamma receptor 1
Synonyms IFNGR1, IFN-gamma-R1, IFN-gamma receptor 1, IFN gamma receptor 1, IFN gamma R1
Calculated Molecular Weight 54 kDa
Observed Molecular Weight 90 kDa
GenBank Accession NumberBC005333
Gene Symbol IFNGR1
Gene ID (NCBI) 3459
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP15260
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)