CoraLite® Plus 488-conjugated IGF2R-Specific Polyclonal antibody
IGF2R-Specific Polyclonal Antibody for
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
Conjugate
CoraLite® Plus 488 Fluorescent Dye
验证数据展示
Planning an IHC experiment? We recommend our IHCeasy IGF2R Ready-To-Use IHC Kit. IGF2R primary antibody included.
For other applications, we recommend the unconjugated version of this antibody, 20253-1-AP
产品信息
CL488-20253 targets IGF2R-Specific in applications and shows reactivity with human samples.
| Tested Applications | Application Description |
| Tested Reactivity | human |
| Immunogen | Peptide 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | insulin-like growth factor 2 receptor |
| Synonyms | CD222, CI Man 6 P receptor, CI MPR, CIMPR, IGF II receptor, IGF2R, IGF2R-Specific, M6P R, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, MPR1, MPRI |
| Calculated Molecular Weight | 274 kDa |
| Observed Molecular Weight | 300 kDa |
| GenBank Accession Number | NM_000876 |
| Gene Symbol | IGF2R |
| Gene ID (NCBI) | 3482 |
| RRID | AB_2919169 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P11717 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
IGF2R, also named as MPRI, CI Man-6-P receptor, CI-MPR, M6PR, IGF-II receptor, M6P/IGF2R, MPR 300 and CD222, belongs to the MRL1/IGF2R family. IGF2R transports of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. IGF2R is a lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. IGF2R acts as a positive regulator of T-cell coactivation, by binding DPP4. The antibody is specific to IGF2R.
