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Host
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Species Reactivity
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Species Reactivity
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Compatible Species
0
Conjugate
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验证数据展示

  • FC experiment of human PBMCs using 98142-1-RR (same clone as 98142-1-PBS)

    FC experiment of human PBMCs using 98142-1-RR (same clone as 98142-1-PBS)

    1x10^6 untreated or IFN gamma, LPS and Brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human IL-1 beta Rabbit Recombinant Antibody (98142-1-RR, Clone: 240902A3) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). Granulocytes were gated. This data was developed using the same antibody clone with 98142-1-PBS in a different storage buffer formulation.

  • FC experiment of human PBMCs using 98142-1-RR (same clone as 98142-1-PBS)

    FC experiment of human PBMCs using 98142-1-RR (same clone as 98142-1-PBS)

    1x10^6 IFN gamma, LPS and Brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human IL-1 beta Rabbit Recombinant Antibody (98142-1-RR, Clone: 240902A3) (red) or Isotype Control (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 unstimulated human PBMCs were intracellularly stained with 0.25 ug Anti-Human IL-1 beta Rabbit Recombinant Antibody (98142-1-RR, Clone: 240902A3) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). Granulocytes were gated. This data was developed using the same antibody clone with 98142-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98142-1-RR

    Affinity and Kinetic Characterization of 98142-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98142-1-RR against Human IL-1 beta were performed. The affinity constant is 4.98 nM.

Anti-Human IL-1 beta Rabbit Recombinant Antibody, PBS Only

IL-1 beta Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98142-1-PBS

产品说明书

CloneNo. 240902A3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

IL1- beta, IL1 beta, IL 1 beta, IL 1, Catabolin

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98142-1-PBS targets IL-1 beta in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 1, beta
别名 IL1- beta, IL1 beta, IL 1 beta, IL 1, Catabolin
计算分子量 269 aa, 31 kDa
GenBank蛋白编号BC008678
基因名称 IL1B
Gene ID (NCBI) 3553
ENSEMBL Gene IDENSG00000125538
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP01584
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. IL-1 Beta(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions.