Mouse IL-17A Recombinant antibody, PBS Only

IL-17A Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 82905-1-PBS

产品说明书

CloneNo. 230038B1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

WB, Indirect ELISA

Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

82905-1-PBS targets IL-17A in WB, Indirect ELISA applications and shows reactivity with mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 17A
别名 Il17a, Interleukin17A, interleukin 17A, Il17, IL 17A
计算分子量17 kDa
观测分子量14 kDa, 17 kDa
GenBank蛋白编号NM-010552
基因名称 Il17a
Gene ID (NCBI) 16171
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ62386
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.

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