IL-19 Monoclonal antibody, PBS Only

IL-19 Monoclonal Antibody for IHC, IF/ICC, IF-P, Indirect ELISA
Cat No. 60278-1-PBS

产品说明书

CloneNo. 8H10H8

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

IHC, IF/ICC, IF-P, Indirect ELISA

IL19, interleukin19, interleukin 19, IL 19, IL 10C

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

60278-1-PBS targets IL-19 in IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, IF/ICC, IF-P, Indirect ELISA Application Description
经测试反应性 human
免疫原 IL-19 fusion protein Ag18887 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 interleukin 19
别名 IL19, interleukin19, interleukin 19, IL 19, IL 10C
计算分子量 177 aa, 20 kDa
GenBank蛋白编号BC153127
基因名称 IL-19
Gene ID (NCBI) 29949
RRIDAB_2881397
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ9UHD0
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.

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