Anti-Human IL-5 Rabbit Recombinant Antibody, PBS Only

IL-5 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98178-1-PBS

产品说明书

CloneNo. 240915D12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

98178-1-PBS targets IL-5 in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 5 (colony-stimulating factor, eosinophil)
别名 IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I
计算分子量 134 aa, 15 kDa
GenBank蛋白编号BC066282
基因名称 IL5
Gene ID (NCBI) 3567
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP05113
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)

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