Anti-Human IL-5 Rabbit Recombinant Antibody

IL-5 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98178-1-RR

产品说明书

CloneNo. 240915D12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive FC (Intra) detected inPMA, Ionomycin and Brefeldin A treated human PBMCs

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98178-1-RR targets IL-5 in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 5 (colony-stimulating factor, eosinophil)
别名 IL5, Interleukin-5, Interleukin 5, IL 5, B-cell differentiation factor I
计算分子量 134 aa, 15 kDa
GenBank蛋白编号BC066282
基因名称 IL5
Gene ID (NCBI) 3567
RRIDAB_3672321
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP05113
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

IL-5 is a 4-α-helix, pleiotropic cytokine that regulates the activities of B cells, eosinophils, and basophils. It is produced mostly by CD4+ T cells, eosinophils, and basophils, and signals through its specific receptor (IL-5R) on target cells to activate downstream JAK/STAT, Btk, and Ras/ERk pathways. Due to its pleiotropic effects, IL-5 plays a role in both innate and adaptive immune responses. It is a strong promoter of eosinophil differentiation, migration, maturation, and survival. Additionally, IL-5 is also capable of stimulating activated B cells to differentiate into antibody-secreting cells. Elevated IL-5 levels are strongly correlated with eosinophilia, which is a hallmark feature of allergy, asthma, and hypersensitivity. (PMID: 21986312, 22174445, 19819937, 16895557)

实验方案

Product Specific Protocols
FC protocol for IL-5 antibody 98178-1-RRDownload protocol
Standard Protocols
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