CD126/IL-6R alpha Recombinant antibody

CD126/IL-6R alpha Uni-rAbTM Recombinant Antibody for WB, ELISA
Cat No. 83688-4-RR

产品说明书

CloneNo. 240734D1

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

WB, ELISA

CD126, IL-6R alpha, 240734D1, IL 6R alpha, IL 6R 1

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inRAW 264.7 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

83688-4-RR targets CD126/IL-6R alpha in WB, ELISA applications and shows reactivity with mouse samples.

经测试应用 WB, ELISA Application Description
经测试反应性 mouse
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 6 receptor
别名 CD126, IL-6R alpha, 240734D1, IL 6R alpha, IL 6R 1
计算分子量 468 aa, 52 kDa
观测分子量65 kDA
GenBank蛋白编号BC132684
基因名称 IL-6R alpha
Gene ID (NCBI) 3570
RRIDAB_3671290
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP08887
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R, the complex of IL-6 and IL-6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while IL-6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892).

实验方案

Product Specific Protocols
WB protocol for CD126/IL-6R alpha antibody 83688-4-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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