• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

    WB analysis of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

    NK-92 cells were subjected to SDS PAGE followed by western blot with 84390-5-RR (IL18R1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84390-5-PBS in a different storage buffer formulation.

  • IF Staining of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

    IF Staining of NK-92 using 84390-5-RR (same clone as 84390-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed NK-92 cells using IL-18R1/CD218a antibody (84390-5-RR, Clone: 241673G6 ) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84390-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84390-5-RR

    Affinity and Kinetic Characterization of 84390-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84390-5-RR against Human IL-18R1/CD218a were performed. The affinity constant is 0.948 nM.

IL-18R1/CD218a Recombinant antibody, PBS Only

IL-18R1/CD218a Uni-rAbTM Recombinant Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 84390-5-PBS

产品说明书

CloneNo. 241673G6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IF/ICC, Indirect ELISA

别名

IL18R1, IL 18R1, IL 18R 1, EC:3.2.2.6, CD218a

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

点击咨询售前客服

点击咨询售后客服

产品信息

84390-5-PBS targets IL-18R1/CD218a in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 human
免疫原 Recombinant Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 18 receptor 1
别名 IL18R1, IL 18R1, IL 18R 1, EC:3.2.2.6, CD218a
计算分子量 541 aa, 62 kDa
观测分子量60-75 kDa
GenBank蛋白编号BC093975
基因名称 IL18R1
Gene ID (NCBI) 8809
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ13478
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IL-18R1 (CD218a) is a component of the interleukin-18 receptor (IL-18R) complex, which is critical for the signaling of IL-18, a pro-inflammatory cytokine. This receptor complex, consisting of IL-18R1 and the IL-18 receptor accessory protein (IL-18RAP), belongs to the immunoglobulin-like family of interleukin-1 receptors (PMID: 35461924). IL-18R1 plays a significant role in inducing the production of interferon-gamma (IFN-γ) and other inflammatory cytokines, contributing to innate and adaptive immune responses (PMID: 2550053). It is also suggested to play a role in hypertension and chronic kidney disease, where the IL-18/IL-18R1 signaling axis may have diagnostic and therapeutic potential (PMID: 35461924).