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验证数据展示

  • FC experiment of human PBMCs using 98053-1-RR (same clone as 98053-1-PBS)

    FC experiment of human PBMCs using 98053-1-RR (same clone as 98053-1-PBS)

    1x10^6 untreated or PMA, Ionomycin and Brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human IL2 Rabbit Recombinant Antibody (98053-1-RR, Clone: 240416E3) and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with CoraLite® Plus 647 Anti-Human CD3. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98053-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98053-1-RR

    Affinity and Kinetic Characterization of 98053-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98053-1-RR against Human IL-2 were performed. The affinity constant is below 1 pM.

Anti-Human IL-2 Rabbit Recombinant Antibody, PBS Only

IL-2 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98053-1-PBS

产品说明书

CloneNo. 240416E3

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

IL2, TCGF, Interleukin-2, interleukin 2, IL 2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98053-1-PBS targets IL-2 in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原 Fusion Protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 interleukin 2
别名 IL2, TCGF, Interleukin-2, interleukin 2, IL 2
计算分子量 153 aa, 18 kDa
GenBank蛋白编号BC070338
基因名称 IL2
Gene ID (NCBI) 3558
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP60568
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-2 (IL-2) is a four-helix bundle, type I cytokine that functions as a growth factor for a wide range of leukocytes. In the immune system, IL-2 is essential for immune homeostasis, normal T regulatory cell function, and self-tolerance. It regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and autoimmune disease. IL-2 signals through heterodimerization of the IL-2Rβ and IL-2Rγ receptor subunits (PMID: 25992858, 24907378, 15034008, 17981641).