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Anti-Human IL-2 Rabbit Recombinant Antibody, PBS Only

IL-2 Uni-rAbTM Recombinant Antibody for FC (Intra)

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC (Intra)

Conjugate

Unconjugated

CloneNo.

240416E3

Cat no : 98053-1-PBS

Print datasheet

Synonyms

IL2, TCGF, Interleukin-2, interleukin 2, IL 2

验证数据展示

  • FC experiment of human PBMCs using 98053-1-RR (same clone as 98053-1-PBS)

    FC experiment of human PBMCs using 98053-1-RR (same clone as 98053-1-PBS)

    1x10^6 untreated or PMA, Ionomycin and Brefeldin A treated human PBMCs were intracellularly stained with 0.25 ug Anti-Human IL2 Rabbit Recombinant Antibody (98053-1-RR, Clone: 240416E3) and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with CoraLite® Plus 647 Anti-Human CD3. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98053-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98053-1-RR

    Affinity and Kinetic Characterization of 98053-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98053-1-RR against Human IL-2 were performed. The affinity constant is below 1 pM.

产品信息

The immunogen of 98053-1-PBS is IL-2 Fusion Protein expressed in E. coli.

Tested Applications FC (Intra) Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name interleukin 2
Synonyms IL2, TCGF, Interleukin-2, interleukin 2, IL 2
Calculated Molecular Weight 153 aa, 18 kDa
GenBank Accession NumberBC070338
Gene Symbol IL2
Gene ID (NCBI) 3558
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP60568
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Interleukin-2 (IL-2) is a four-helix bundle, type I cytokine that functions as a growth factor for a wide range of leukocytes. In the immune system, IL-2 is essential for immune homeostasis, normal T regulatory cell function, and self-tolerance. It regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and autoimmune disease. IL-2 signals through heterodimerization of the IL-2Rβ and IL-2Rγ receptor subunits (PMID: 25992858, 24907378, 15034008, 17981641).