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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 68348-1-Ig (same clone as 68348-1-PBS)

    WB analysis using 68348-1-Ig (same clone as 68348-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68348-1-Ig (IRSp53 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68348-1-PBS in a different storage buffer formulation.

IRSp53 Monoclonal antibody, PBS Only

IRSp53 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68348-1-PBS

产品说明书

CloneNo. 1D4G1

宿主/亚型

Mouse / IgG1

种属反应性

Human, Mouse, Rat, Rabbit

应用

WB, Indirect ELISA

别名

BAI associated protein 2, BAI1 associated protein 2, BAIAP2, BAP2, Fas ligand associated factor 3, FLAF3, Insulin receptor substrate p53, IRS 58, IRSP53, IRSp53/58, Protein BAP2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

68348-1-PBS targets IRSp53 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat, Rabbit samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat, Rabbit
免疫原 IRSp53 fusion protein Ag25161 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 BAI1-associated protein 2
别名 BAI associated protein 2, BAI1 associated protein 2, BAIAP2, BAP2, Fas ligand associated factor 3, FLAF3, Insulin receptor substrate p53, IRS 58, IRSP53, IRSp53/58, Protein BAP2
计算分子量 61 kDa
观测分子量53 kDa
GenBank蛋白编号BC014020
基因名称 IRSp53
Gene ID (NCBI) 10458
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ9UQB8
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

IRSp53 (also known as BAIAP2) is a multi-domain adaptor protein that originally identified as a 58/53-kDa substrate of insulin-receptor kinase in the hamster (PMID: 10332026). As a BAI1-binding protein, IRSp53 plays an important role in linking between membrane and cytoskeleton in the process of neuronal growth (PMID: 10343108). IRSp53 is necessary for Cdc42-mediated reorganization of the actin cytoskeleton and for Rac1-mediated membrane ruffling. Alternatively spliced isoforms of IRSp53 exist. IRSp53 has been implicated in several psychiatric disorders, including autism spectrum disorders (ASDs), schizophrenia, and attention deficit/hyperactivity disorder (ADHD) (PMID: 26275848).