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  • Featured Product
  • KD/KO Validated

KEPI Polyclonal antibody, PBS Only

KEPI Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 24933-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 24933-1-AP (same clone as 24933-1-PBS)

    WB analysis using 24933-1-AP (same clone as 24933-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24933-1-AP (KEPI antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24933-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 24933-1-AP (same clone as 24933-1-PBS)

    WB analysis of HeLa using 24933-1-AP (same clone as 24933-1-PBS)

    WB result of KEPI antibody (24933-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-KEPI transfected HeLa cells. This data was developed using the same antibody clone with 24933-1-PBS in a different storage buffer formulation.

产品信息

24933-1-PBS targets KEPI in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen KEPI fusion protein Ag20645 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name protein phosphatase 1, regulatory (inhibitor) subunit 14C
Synonyms
Calculated Molecular Weight 18 kDa
Observed Molecular Weight20-22 kDa
GenBank Accession NumberBC015773
Gene Symbol PPP1R14C
Gene ID (NCBI) 81706
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8TAE6
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PPP1R14C, found as a morphine‐regulated brain gene, encodes protein phosphatase 1 regulatory inhibitor subunit 14C, and is identified as a potent inhibitor of PP1. Horvath and colleagues reported that PPP1R14C inhibited the release of neurotransmitters and promoted neuronal exocytosis by retaining synaptosome associated protein 25 (SNAP25) at a phosphorylated state. Moreover, overexpression of PPP1R14C increased the phosphorylation of RB transcriptional co‐repressor 1 (RB1) to protect leukemic cells from chemotherapy.