验证数据展示
产品信息
67009-1-PBS targets KIF5A in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.
经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat, pig |
免疫原 | KIF5A fusion protein Ag15682 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | kinesin family member 5A |
别名 | D12S1889, KIF5A, kinesin family member 5A, Kinesin heavy chain isoform 5A, MY050, Neuronal kinesin heavy chain, NKHC, NKHC1, SPG10 |
计算分子量 | 1032 aa, 117 kDa |
观测分子量 | 130 kDa |
GenBank蛋白编号 | BC146670 |
基因名称 | KIF5A |
Gene ID (NCBI) | 3798 |
RRID | AB_2882326 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q12840 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Kinesin superfamily proteins (KIFs) are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. KIF5A is expressed exclusively in neurons and transports neuronal cargoes into axons and dendrites. KIF5A mutations have been associated with Charcot-Marie-Tooth Type 2, an axonal peripheral neuropathy characterized by progressive loss of peripheral sensation and muscle wasting.