Anti-Mouse LAG-3/CD223 Rabbit Recombinant Antibody

LAG-3/CD223 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

mouse

Applications

FC

Conjugate

Unconjugated

CloneNo.

241294E11

Cat no : 98167-1-RR

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Synonyms

CD223, LAG-3, Ly66, Lag3, LAG 3



经过测试的应用

Positive FC detected inAnti-CD3/CD28 treated mouse splenocytes

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98167-1-RR targets LAG-3/CD223 in FC applications and shows reactivity with mouse samples.

Tested Applications FC Application Description
Tested Reactivity mouse
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name lymphocyte-activation gene 3
Synonyms CD223, LAG-3, Ly66, Lag3, LAG 3
Calculated Molecular Weight57kDa
GenBank Accession NumberNM_008479.2
Gene Symbol CD223
Gene ID (NCBI) 16768
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ61790
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

背景介绍

Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).

实验方案

Product Specific Protocols
FC protocol for LAG-3/CD223 antibody 98167-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols