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LAIR1 Monoclonal antibody, PBS Only

LAIR1 Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

WB, IHC, IF/ICC, IF-P, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A5D1

Cat no : 67220-1-PBS

Print datasheet

Synonyms

Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, LAIR 1, hLAIR1, CD305

验证数据展示

  • WB analysis of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    WB analysis of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    THP-1 cells were subjected to SDS PAGE followed by western blot with 67220-1-Ig (LAIR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 67220-1-Ig (LAIR1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 67220-1-Ig (LAIR1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using LAIR1 antibody (67220-1-Ig, Clone: 1A5D1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using LAIR1 antibody (67220-1-Ig, Clone: 1A5D1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    IF Staining of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using LAIR1 antibody (67220-1-Ig, Clone: 1A5D1 ) at dilution of 1:2000 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (RGAM002). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

产品信息

67220-1-PBS targets LAIR1 in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, IF/ICC, IF-P, Indirect ELISA Application Description
Tested Reactivity human
Immunogen LAIR1 fusion protein Ag14459 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name leukocyte-associated immunoglobulin-like receptor 1
Synonyms Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, LAIR 1, hLAIR1, CD305
Calculated Molecular Weight 287 aa, 31 kDa
Observed Molecular Weight 40-50 kDa
GenBank Accession NumberBC027899
Gene Symbol LAIR1
Gene ID (NCBI) 3903
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ6GTX8
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).