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LAIR1 Monoclonal antibody, PBS Only

LAIR1 Monoclonal Antibody for WB,Indirect ELISA,IHC,IF

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

WB,Indirect ELISA,IHC,IF

Conjugate

Unconjugated

CloneNo.

1A5D1

Cat No : 67220-1-PBS

Print datasheet

Synonyms

CD305, hLAIR1, LAIR 1, LAIR1

验证数据展示

  • WB analysis of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    WB analysis of THP-1 using 67220-1-Ig (same clone as 67220-1-PBS)

    THP-1 cells were subjected to SDS PAGE followed by western blot with 67220-1-Ig (LAIR1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 67220-1-Ig (LAIR1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IHC staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 67220-1-Ig (LAIR1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using LAIR1 antibody (67220-1-Ig, Clone: 1A5D1 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

  • IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    IF Staining of human tonsillitis using 67220-1-Ig (same clone as 67220-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using LAIR1 antibody (67220-1-Ig, Clone: 1A5D1 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67220-1-PBS in a different storage buffer formulation.

产品信息

67220-1-PBS targets LAIR1 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB,Indirect ELISA,IHC,IF Application Description
Tested Reactivity Human
Immunogen LAIR1 fusion protein Ag14459 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name leukocyte-associated immunoglobulin-like receptor 1
Synonyms CD305, hLAIR1, LAIR 1, LAIR1
Calculated Molecular Weight 287 aa, 31 kDa
Observed Molecular Weight 40-50 kDa
GenBank Accession NumberBC027899
Gene Symbol LAIR1
Gene ID (NCBI) 3903
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ6GTX8
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs (PMID: 9285412). LAIR1 is expressed on the majority of human PBMCs, including NK, T, B, monocytes, and dendritic cells, as well as the majority of thymocytes (PMID: 10229813). It functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of NK cells, B cells and T cells. LAIR1 is a collagen receptor (PMID: 16754721). Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR1 (PMID: 21955987).