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  • Featured Product
  • KD/KO Validated

LDLR Monoclonal antibody, PBS Only

LDLR Monoclonal Antibody for WB, IHC, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

CloneNo.

1A2A3

Cat no : 66414-1-PBS

Print datasheet

Synonyms

FH, FHC, LDL receptor, LDLR

验证数据展示

  • WB analysis of HeLa using 66414-1-Ig (same clone as 66414-1-PBS)

    WB analysis of HeLa using 66414-1-Ig (same clone as 66414-1-PBS)

    WB result of LDLR antibody (66414-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LDLR transfected HeLa cells. This data was developed using the same antibody clone with 66414-1-PBS in a different storage buffer formulation.

  • WB analysis using 66414-1-Ig (same clone as 66414-1-PBS)

    WB analysis using 66414-1-Ig (same clone as 66414-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66414-1-Ig (LDLR antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66414-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66414-1-Ig (same clone as 66414-1-PBS)

    IHC staining of human liver using 66414-1-Ig (same clone as 66414-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66414-1-Ig (LDLR Antibody) at dilution of 1:400 (under 10x lens). This data was developed using the same antibody clone with 66414-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 66414-1-Ig (same clone as 66414-1-PBS)

    IHC staining of human liver using 66414-1-Ig (same clone as 66414-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 66414-1-Ig (LDLR Antibody) at dilution of 1:400 (under 40x lens). This data was developed using the same antibody clone with 66414-1-PBS in a different storage buffer formulation.

66414-1-Ig

产品信息

66414-1-PBS targets LDLR in WB, IHC, ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, ELISA Application Description
Tested Reactivity human
Immunogen LDLR fusion protein Ag1236 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name low density lipoprotein receptor
Synonyms FH, FHC, LDL receptor, LDLR
Calculated Molecular Weight 95 kDa
Observed Molecular Weight 120 kDa, 160 kDa
GenBank Accession NumberBC014514
Gene Symbol LDLR
Gene ID (NCBI) 3949
ENSEMBL Gene IDENSG00000130164
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP01130
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.