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LEPR Recombinant antibody, PBS Only

LEPR Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241692G9

Cat no : 84464-4-PBS

Print datasheet

Synonyms

LEP-R, LEP R, HuB219, DB, CD295

验证数据展示

  • WB analysis using 84464-4-RR (same clone as 84464-4-PBS)

    WB analysis using 84464-4-RR (same clone as 84464-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84464-4-RR (LEPR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84464-4-PBS in a different storage buffer formulation.

产品信息

84464-4-PBS targets LEPR in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen Recombinant Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name leptin receptor
Synonyms LEP-R, LEP R, HuB219, DB, CD295
Calculated Molecular Weight 132 kDa
Observed Molecular Weight120 kDa
GenBank Accession NumberNM_002303
Gene Symbol LEPR
Gene ID (NCBI) 3953
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP48357
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The hormone leptin, secreted predominantly from adipose tissue, plays a crucial role in the regulation of numerous neuroendocrine functions, from energy homeostasis to reproduction (PMID: 22249808). Leptin acts through the leptin receptor (LEPR, also known as OB-R), a single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, LEPR mediates signaling through JAK2/STAT3 (PMID: 9102398). LEPR plays an important role in the regulation of glucose homeostasis via feeding and adiposity. Alternatively spliced transcript variants encoding different isoforms of LEPR have been described.