验证数据展示
产品信息
66705-1-PBS targets LIG4 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.
Tested Applications | WB, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | Human |
Immunogen | LIG4 fusion protein Ag3385 种属同源性预测 |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Full Name | ligase IV, DNA, ATP-dependent |
Synonyms | DNA ligase 4, DNA ligase IV, LIG4, ligase IV, DNA, ATP dependent |
Calculated Molecular Weight | 911 aa, 104 kDa |
Observed Molecular Weight | 100-104 kDa |
GenBank Accession Number | BC037491 |
Gene Symbol | LIG4 |
Gene ID (NCBI) | 3981 |
RRID | AB_2882057 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P49917 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand brdownloadeaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4.