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验证数据展示

  • WB analysis of Jurkat using 17958-1-AP (same clone as 17958-1-PBS)

    WB analysis of Jurkat using 17958-1-AP (same clone as 17958-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 17958-1-AP (LOX antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17958-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 17958-1-AP (same clone as 17958-1-PBS)

    IHC staining of human stomach cancer using 17958-1-AP (same clone as 17958-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 17958-1-AP (LOX antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17958-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with LOX antibody included
  • IP experiment of mouse skeletal muscle using 17958-1-AP (same clone as 17958-1-PBS)

    IP experiment of mouse skeletal muscle using 17958-1-AP (same clone as 17958-1-PBS)

    IP result of anti-LOX (IP:17958-1-AP, 3ug; Detection:17958-1-AP 1:500) with mouse skeletal muscle tissue lysate 2000ug. This data was developed using the same antibody clone with 17958-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

LOX Polyclonal antibody, PBS Only

LOX Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 17958-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

Protein-lysine 6-oxidase, short form, Protein-lysine 6-oxidase, long form, Protein-lysine 6-oxidase, lysyl oxidase, EC:1.4.3.13

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy LOX Ready-To-Use IHC Kit. LOX primary antibody included.

产品信息

17958-1-PBS targets LOX in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 LOX fusion protein Ag12479 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 lysyl oxidase
别名 Protein-lysine 6-oxidase, short form, Protein-lysine 6-oxidase, long form, Protein-lysine 6-oxidase, lysyl oxidase, EC:1.4.3.13
计算分子量 417 aa, 47 kDa
观测分子量 32 kDa, 45-47 kDa
GenBank蛋白编号BC074872
基因名称 LOX
Gene ID (NCBI) 4015
RRIDAB_2234541
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP28300
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LOX is a member of a multigene family (LOX, LOXL, LOXL2, LOXL3, and LOXL4). Lysyl oxidase (LOX), a copper-dependent enzyme, plays a critical role in the formation and repair of the extracellularmatrix (ECM) by catalyzing the crosslinking of elastin and collagen. LOX expression appears to be upregulated in malignancies and has recently been suggested to play a role in regulating tumor metastasis. It is synthesized as a 50 kDa proenzyme, secreted, and processed into an 32 kDa mature, active enzyme and an 18-kDa propeptide.