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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis using 68323-1-Ig (same clone as 68323-1-PBS)

    WB analysis using 68323-1-Ig (same clone as 68323-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68323-1-Ig (LRRC8C antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 68323-1-Ig (same clone as 68323-1-PBS)

    IF Staining of HepG2 using 68323-1-Ig (same clone as 68323-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LRRC8C antibody (68323-1-Ig, Clone: 4A6A4 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 68323-1-PBS in a different storage buffer formulation.

LRRC8C Monoclonal antibody, PBS Only

LRRC8C Monoclonal Antibody for WB, IF/ICC, Indirect ELISA
Cat No. 68323-1-PBS

产品说明书

CloneNo. 4A6A4

宿主/亚型

Mouse / IgG2b

种属反应性

Human

应用

WB, IF/ICC, Indirect ELISA

别名

AD158, DKFZp586J1119, FAD158, LRRC8C

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

68323-1-PBS targets LRRC8C in WB, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.

经测试应用 WB, IF/ICC, Indirect ELISA Application Description
经测试反应性 Human
免疫原 LRRC8C fusion protein Ag17001 种属同源性预测
宿主/亚型 Mouse / IgG2b
抗体类别 Monoclonal
产品类型 Antibody
全称 leucine rich repeat containing 8 family, member C
别名 AD158, DKFZp586J1119, FAD158, LRRC8C
计算分子量 803 aa, 92 kDa
观测分子量105 kDa
GenBank蛋白编号BC113973
基因名称 LRRC8C
Gene ID (NCBI) 84230
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ8TDW0
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRRC8C (Leucine-rich repeat-containing protein 8C), also known as AD158, is a non-essential component of the volume-regulated anion channel (VRAC, also known as VSOAC channel), which is required to maintain a constant cell volume in response to extracellular or intracellular permeability changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PMID:24790029; 26824658; 28193731).