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验证数据展示

  • IF Staining of HepG2 using CL488-21601

    IF Staining of HepG2 using CL488-21601

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using CoraLite® Plus 488 LRRC8C antibody (CL488-21601) at dilution of 1:200.

CoraLite® Plus 488-conjugated LRRC8C Polyclonal antibody

LRRC8C Polyclonal Antibody for IF/ICC
Cat No. CL488-21601

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IF/ICC

别名

AD158, DKFZp586J1119, FAD158, LRRC8C

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格: 

-/ -

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经过测试的应用

Positive IF/ICC detected inHepG2 cells
For other applications, we recommend the unconjugated version of this antibody, 21601-1-AP

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-21601 targets LRRC8C in IF/ICC applications and shows reactivity with human, mouse, rat samples.

经测试应用 IF/ICC Application Description
经测试反应性 human, mouse, rat
免疫原 LRRC8C fusion protein Ag16213 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 leucine rich repeat containing 8 family, member C
别名 AD158, DKFZp586J1119, FAD158, LRRC8C
计算分子量 803 aa, 92 kDa
观测分子量92 kDa
GenBank蛋白编号BC113973
基因名称 LRRC8C
Gene ID (NCBI) 84230
RRIDAB_3084053
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8TDW0
储存缓冲液 PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA , pH 7.3
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LRRC8C (Leucine-rich repeat-containing protein 8C), also known as AD158, is a non-essential component of the volume-regulated anion channel (VRAC, also known as VSOAC channel), which is required to maintain a constant cell volume in response to extracellular or intracellular permeability changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PMID:24790029; 26824658; 28193731).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 LRRC8C antibody CL488-21601Download protocol
Standard Protocols
Click here to view our Standard Protocols