验证数据展示
产品信息
13600-1-PBS targets LSAMP in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | LSAMP fusion protein Ag4542 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | limbic system-associated membrane protein |
别名 | |
计算分子量 | 338 aa, 37 kDa |
观测分子量 | 64-68 kDa |
GenBank蛋白编号 | BC033803 |
基因名称 | LSAMP |
Gene ID (NCBI) | 4045 |
RRID | AB_10597712 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q13449 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
LSAMP, also known as LAMP, is a 64-68 kDa heavily glycosylated neural cell adhesion molecule expressed on the neuronal dendrites and somata (PMID: 1688937; 8666243). LSAMP is a member of the IgLON family. The amino acid sequence of LSAMP is highly conserved among species. Human LSAMP shares 99% amino acid sequence identity with rodent LSAMP. The impact of LSAMP protein on neurite outgrowth and neuronal connectivity has been established in a wide spectrum of psychiatric disorders in humans (PMID: 26136648). In mice, lack of LSAMP protein seemingly leads to a deterioration in the ability to adapt to novel stressful environments and stimuli (PMID: 22155487).