验证数据展示
产品信息
29928-1-PBS targets M-cadherin in WB, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IF-P, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | M-cadherin fusion protein Ag25763 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | cadherin 15, type 1, M-cadherin (myotubule) |
别名 | CDH15, Cadherin 14, Cadherin 15, Cadherin-14, Cadherin-15 |
计算分子量 | 89 kDa |
观测分子量 | 130 kDa |
GenBank蛋白编号 | BC008951 |
基因名称 | M-cadherin |
Gene ID (NCBI) | 1013 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P55291 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. M-cadherin (muscle cadherin), also known as CDH15 (cadherin-15), is a 124-kDa type I transmembrane glycoprotein that is highly expressed in developing skeletal muscle, satellite cells, and cerebellum (PMID: 9545347; 12052883). It associates with β-catenin and functions as a cell-cell adhesion molecule in a homophilic and specific manner (PMID: 9545347). M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation (PMID: 1840697).