MALT1 Monoclonal antibody

MALT1 Monoclonal Antibody for WB, IHC, IF/ICC, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human and More (1)

Applications

WB, IHC, IF/ICC, ELISA and More (1)

Conjugate

Unconjugated

CloneNo.

4D3F6

Cat no : 66225-1-Ig

Print datasheet

Synonyms

MALT1, MLT, MLT1, Paracaspase



经过测试的应用

Positive WB detected inHeLa cells, Jurkat cells, K-562 cells
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF/ICC detected inHeLa cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)/ICCIF/ICC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

66225-1-Ig targets MALT1 in WB, IHC, IF/ICC, CoIP, ELISA applications and shows reactivity with human samples.

Tested Applications WB, IHC, IF/ICC, ELISA Application Description
Cited ApplicationsIHC, CoIP
Tested Reactivity human
Cited Reactivityhuman, mouse
Immunogen MALT1 fusion protein Ag20632 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name mucosa associated lymphoid tissue lymphoma translocation gene 1
Synonyms MALT1, MLT, MLT1, Paracaspase
Calculated Molecular Weight 824 aa, 92 kDa
Observed Molecular Weight 92-100 kDa
GenBank Accession NumberBC030143
Gene Symbol MALT1
Gene ID (NCBI) 10892
RRIDAB_2881616
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9UDY8
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 belongs to caspase-like protein superfamily.MALT1 plays a potential role in the regulation of apoptosis and induces NFKB activation and required for the normal development of B cells and for the activation of the IKK complex.It acts as a caspase and mediates additional functions related to T cell activation, cleaving both the ubiquitin editing enzyme,TNFAIP3,and the C terminus of BCL10 .It has two isoforms.Researches showed that inhibition of MALT1 blocks A20 and BCL10 cleavage, reduces NFKB activity, and decreases the expression of NFKB targets BCLXL.

实验方案

Product Specific Protocols
WB protocol for MALT1 antibody 66225-1-IgDownload protocol
IHC protocol for MALT1 antibody 66225-1-IgDownload protocol
IF protocol for MALT1 antibody 66225-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
human,mouseIHC,CoIP

Cell Biol Toxicol

The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway

Authors - Yinghui Wang
humanIHC

Front Cell Dev Biol

Targeting MALT1 Suppresses the Malignant Progression of Colorectal Cancer via miR-375/miR-365a-3p/NF-κB Axis.

Authors - Rui Qian