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MCL1 Recombinant antibody, PBS Only

MCL1 Recombinant Antibody for WB,Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

5P13

Cat No : 82695-4-PBS

Print datasheet

Synonyms

EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM

验证数据展示

  • WB analysis using 82695-4-RR (same clone as 82695-4-PBS)

    WB analysis using 82695-4-RR (same clone as 82695-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 82695-4-RR (MCL1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82695-4-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy MCL1 Ready-To-Use IHC Kit. MCL1 primary antibody included.

产品信息

82695-4-PBS targets MCL1 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human
Immunogen MCL1 fusion protein Ag10397 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM
Calculated Molecular Weight 350 aa, 37 kDa
Observed Molecular Weight40 kDa
GenBank Accession NumberBC107735
Gene Symbol MCL1
Gene ID (NCBI) 4170
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ07820
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumor malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. MCL-1 can be alternatively spliced into a long form (MCL-1L, 40 kDa) or a short form (MCL-1S, 30 kDa). (PMID: 15467463, PMID: 15147382)