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  • Featured Product
  • KD/KO Validated

MCPH/BRIT1 Polyclonal antibody, PBS Only

MCPH/BRIT1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 11962-1-PBS

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Synonyms

验证数据展示

  • WB analysis of HeLa using 11962-1-AP (same clone as 11962-1-PBS)

    WB analysis of HeLa using 11962-1-AP (same clone as 11962-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 11962-1-AP (BRIT1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11962-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 11962-1-AP (same clone as 11962-1-PBS)

    IHC staining of human prostate cancer using 11962-1-AP (same clone as 11962-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer using 11962-1-AP (BRIT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11962-1-PBS in a different storage buffer formulation.

产品信息

11962-1-PBS targets MCPH/BRIT1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen MCPH/BRIT1 fusion protein Ag2567 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name microcephalin 1
Synonyms
Calculated Molecular Weight 93 kDa
Observed Molecular Weight 66 kDa, 100 kDa
GenBank Accession NumberBC030702
Gene Symbol MCPH1
Gene ID (NCBI) 79648
RRIDAB_2142989
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8NEM0
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Primary microcdphaly refers to the clinical finding of a head circumference less than 3 standard deviations(SD) below the age- and sex-related mean, present at birth. MCPH1, the fisrt gene identified as causative for primary microcephaly, encodes a multifunctional protein that notably is linked to DNA damage checkpoint, DNA repair by homologous recombination and DNA transcription. MCPH1 is associated with premature chromosome condensation in particular. There are three mainly isoforms encoded by MCPH1 gene, full-length MCPH1 (MCPH1-FL) (~100kd), lacking the C-terminal BRCTisoform 2(~70kd) and lacking middle region isoform 3(~50kd).(PMID: 22952573 )