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验证数据展示

  • WB analysis of HeLa using 11962-1-AP (same clone as 11962-1-PBS)

    WB analysis of HeLa using 11962-1-AP (same clone as 11962-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 11962-1-AP (BRIT1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11962-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 11962-1-AP (same clone as 11962-1-PBS)

    IHC staining of human prostate cancer using 11962-1-AP (same clone as 11962-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer using 11962-1-AP (BRIT1 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 11962-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

MCPH/BRIT1 Polyclonal antibody, PBS Only

MCPH/BRIT1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 11962-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11962-1-PBS targets MCPH/BRIT1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 MCPH/BRIT1 fusion protein Ag2567 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 microcephalin 1
别名
计算分子量 93 kDa
观测分子量 66 kDa, 100 kDa
GenBank蛋白编号BC030702
基因名称 MCPH1
Gene ID (NCBI) 79648
RRIDAB_2142989
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8NEM0
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Primary microcdphaly refers to the clinical finding of a head circumference less than 3 standard deviations(SD) below the age- and sex-related mean, present at birth. MCPH1, the fisrt gene identified as causative for primary microcephaly, encodes a multifunctional protein that notably is linked to DNA damage checkpoint, DNA repair by homologous recombination and DNA transcription. MCPH1 is associated with premature chromosome condensation in particular. There are three mainly isoforms encoded by MCPH1 gene, full-length MCPH1 (MCPH1-FL) (~100kd), lacking the C-terminal BRCTisoform 2(~70kd) and lacking middle region isoform 3(~50kd).(PMID: 22952573 )