验证数据展示
产品信息
24721-1-PBS targets MDC1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | MDC1 fusion protein Ag20135 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | mediator of DNA damage checkpoint 1 |
Synonyms | |
Calculated Molecular Weight | 2089 aa, 227 kDa |
GenBank Accession Number | BC152556 |
Gene Symbol | MDC1 |
Gene ID (NCBI) | 9656 |
RRID | AB_2879688 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q14676 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
MDC1, also named as KIAA0170 or NFBD1, is a 2089 amino acid protein, which contains two BRCT domains and one FHA domain. MDC1 localizes in the nucleus and is highly expressed in testis. MDC1 is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. MDC1 may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked.