验证数据展示
产品信息
84272-1-PBS targets METTL1 in WB, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, IF/ICC, FC (Intra), Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | METTL1 fusion protein Ag7055 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | methyltransferase like 1 |
别名 | 241108G8, C12orf1, EC:2.1.1.-, EC:2.1.1.33, methyltransferase like 1 |
计算分子量 | 31 kDa |
观测分子量 | 31-35 kDa |
GenBank蛋白编号 | BC000550 |
基因名称 | METTL1 |
Gene ID (NCBI) | 4234 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q9UBP6 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
METTL1 methyltransferase mediates m7G methylation within miRNAs and regulates cell migration via its catalytic activity. METTL1 can be inactivated by phosphorylation at Ser27 by protein kinase B (PKBα). Overexpression of METTL1 is widely observed among human cancers. It is also crucial for the regulation of chemoresistance in cancer treatment. In addition, mutations in the human N7-methylguanosine (m7G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation.