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验证数据展示

  • WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon cancer using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human colon cancer using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 60055-1-Ig (MGP antibody) at dilution of 1:800 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • Cytometric bead array sample test of MP51512-1

    Cytometric bead array sample test of MP51512-1

    Cytometric bead array sample test of MP51512-1, MGP Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60055-1-PBS. Detection antibody: 60055-2-PBS.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of mouse brain using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed frozen OCT-embedded mouse brain tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:800 and CoraLite®594-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-3). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of mouse brain using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed frozen OCT-embedded mouse brain tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of H9C2 using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of H9C2 using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed H9C2 cells using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1), CL594-Phalloidin (red). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of AC16 using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of AC16 using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed AC16 cells using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1), CL594-Phalloidin (red). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • Cytometric bead array standard curve of MP51512-1

    Cytometric bead array standard curve of MP51512-1

    Cytometric bead array standard curve of MP51512-1, MGP Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60055-1-PBS. Detection antibody: 60055-2-PBS. Standard:Ag1091. Range: 1.563-100 ng/mL.

  • Affinity and Kinetic Characterization of 60055-1-Ig

    Affinity and Kinetic Characterization of 60055-1-Ig

    Biolayer interferometry (BLl) kinetic assays of 60055-1-Ig against Human MGP were performed. The Affinity Constant is 5.42 nM.

  • Featured Product
  • KD/KO验证

MGP Monoclonal antibody, PBS Only (Capture)

MGP Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, IF-Fro, Cytometric bead array, Indirect ELISA
Cat No. 60055-1-PBS

产品说明书

CloneNo. 1A1C3

宿主/亚型

Mouse / IgG2a

种属反应性

human, mouse

应用

WB, IHC, IF/ICC, IF-P, IF-Fro, Cytometric bead array, Indirect ELISA

别名

GIG36, 1A1C3, Cell growth-inhibiting gene 36 protein, matrix Gla protein, MGLAP

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

60055-1-PBS targets MGP as part of a matched antibody pair:

MP51512-1: 60055-1-PBS capture and 60055-2-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, IHC, IF/ICC, IF-P, IF-Fro, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag1091

Product name: Recombinant human MGP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-103 aa of BC005272

Sequence: MKSLILLAILAALAVVTLCYESHESMESYELNPFINRRNANTFISPQQRWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYFRKRRGAK

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 matrix Gla protein
别名 GIG36, 1A1C3, Cell growth-inhibiting gene 36 protein, matrix Gla protein, MGLAP
计算分子量 103 aa, 13 kDa
观测分子量 12 kDa
GenBank蛋白编号BC005272
基因名称 MGP
Gene ID (NCBI) 4256
RRIDAB_2143330
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP08493
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

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