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  • Featured Product
  • KD/KO Validated

MGP Monoclonal antibody, PBS Only

MGP Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human, mouse

Applications

WB, IHC, IF-P, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1A1C3

Cat no : 60055-1-PBS

Print datasheet

Synonyms

GIG36, MGLAP, matrix Gla protein, Cell growth-inhibiting gene 36 protein, 1A1C3

验证数据展示

  • WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    WB analysis using 60055-1-Ig (same clone as 60055-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60055-1-Ig (MGP antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 10x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    IHC staining of human gliomas using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 60055-1-Ig (MGP Antibody) at dilution of 1:800 (under 40x lens). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    IF Staining of mouse kidney using 60055-1-Ig (same clone as 60055-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse kidney tissue using MGP antibody (60055-1-Ig, Clone: 1A1C3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 60055-1-PBS in a different storage buffer formulation.

产品信息

60055-1-PBS targets MGP in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, IF-P, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen MGP fusion protein Ag1091 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name matrix Gla protein
Synonyms GIG36, MGLAP, matrix Gla protein, Cell growth-inhibiting gene 36 protein, 1A1C3
Calculated Molecular Weight 103 aa, 13 kDa
Observed Molecular Weight 12 kDa
GenBank Accession NumberBC005272
Gene Symbol MGP
Gene ID (NCBI) 4256
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP08493
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.