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Anti-Human MICA/MICB Rabbit Recombinant Antibody, PBS Only

MICA/MICB Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

240735D5

Cat no : 98110-1-PBS

Print datasheet

Synonyms

MICA, PERB11.1, MIC A, 240735D5

验证数据展示

  • FC experiment of HeLa using 98110-1-RR (same clone as 98110-1-PBS)

    FC experiment of HeLa using 98110-1-RR (same clone as 98110-1-PBS)

    1x10^6 HeLa cells (left) or Jurkat cells (right) were surface stained with 0.25 ug Anti-Human MICA/MICB Rabbit Recombinant Antibody (98110-1-RR, Clone: 240735D5) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98110-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98110-1-RR

    Affinity and Kinetic Characterization of 98110-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98110-1-RR against Human MICA were performed. The affinity constant is 0.907 nM.

产品信息

98110-1-PBS targets MICA/MICB in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Fusion Protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name MHC class I polypeptide-related sequence A
Synonyms MICA, PERB11.1, MIC A, 240735D5
Calculated Molecular Weight43 kDa
GenBank Accession NumberAAH16929.1
Gene Symbol MICA
Gene ID (NCBI) 4276
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). This antibody recognizes both MICA and MICB.