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MLXIPL Polyclonal antibody, PBS Only

MLXIPL Polyclonal Antibody for WB, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 13256-1-PBS

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Synonyms

验证数据展示

  • WB analysis using 13256-1-AP (same clone as 13256-1-PBS)

    WB analysis using 13256-1-AP (same clone as 13256-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13256-1-AP (MLXIPL antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13256-1-PBS in a different storage buffer formulation.

  • IP experiment of HepG2 using 13256-1-AP (same clone as 13256-1-PBS)

    IP experiment of HepG2 using 13256-1-AP (same clone as 13256-1-PBS)

    IP result of anti-MLXIPL (IP:13256-1-AP, 4ug; Detection:13256-1-AP 1:1000) with HepG2 cells lysate 3600ug. This data was developed using the same antibody clone with 13256-1-PBS in a different storage buffer formulation.

产品信息

13256-1-PBS targets MLXIPL in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IP, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen MLXIPL fusion protein Ag3481 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name MLX interacting protein-like
Synonyms
Calculated Molecular Weight 852 aa, 93 kDa
Observed Molecular Weight 65 kDa
GenBank Accession NumberBC012925
Gene Symbol MLXIPL
Gene ID (NCBI) 51085
RRIDAB_2266665
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NP71
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Carbohydrate response element-binding protein (ChREBP), also known as MLXIPL, is a glucose-responsive transcription factor that has a fundamental role in the glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. Circulating blood glucose levels affect ChREBP activity in hepatocytes largely by post-translational mechanisms that include phosphorylation-dependent subcellular localization [PMID:21665952]. It enhances expression of the liver pyruvate kinase (LPK) gene and all lipogenic enzyme genes resulting in the conversion of excess dietary carbohydrate into triglycerides that can be stored as fat [PMID:15118080]. Molecular Weight of ChREBP splice variants: 62/78/91/93 kDa.