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  • Featured Product
  • KD/KO Validated

MMP12 Monoclonal antibody, PBS Only

MMP12 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1C6B5

Cat no : 66930-1-PBS

Print datasheet

Synonyms

HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12

验证数据展示

  • WB analysis using 66930-1-Ig (same clone as 66930-1-PBS)

    WB analysis using 66930-1-Ig (same clone as 66930-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66930-1-Ig (MMP12 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66930-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy MMP12 Ready-To-Use IHC Kit. MMP12 primary antibody included.

产品信息

66930-1-PBS targets MMP12 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human
Immunogen MMP12 fusion protein Ag19068 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name matrix metallopeptidase 12 (macrophage elastase)
Synonyms HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12
Calculated Molecular Weight 470 aa, 54 kDa
Observed Molecular Weight 54 kDa, 45 kDa
GenBank Accession NumberBC112301
Gene Symbol MMP12
Gene ID (NCBI) 4321
RRIDAB_2882256
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP39900
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).