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MRE11A Monoclonal antibody, PBS Only

MRE11A Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B12B2

Cat no : 67570-1-PBS

Print datasheet

Synonyms

ATLD, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11A, MRE11B

验证数据展示

  • WB analysis using 67570-1-Ig (same clone as 67570-1-PBS)

    WB analysis using 67570-1-Ig (same clone as 67570-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67570-1-Ig (MRE11A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67570-1-PBS in a different storage buffer formulation.

产品信息

67570-1-PBS targets MRE11A in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, Mouse, Rat
Immunogen MRE11A fusion protein Ag28847 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Synonyms ATLD, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11A, MRE11B
Observed Molecular Weight 81 kDa
GenBank Accession NumberBC063458
Gene Symbol MRE11A
Gene ID (NCBI) 4361
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP49959
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)