MRE11A Monoclonal antibody, PBS Only

MRE11A Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67570-1-PBS

产品说明书

CloneNo. 1B12B2

宿主/亚型

Mouse / IgG1

种属反应性

Human, Mouse, Rat

应用

WB, Indirect ELISA

ATLD, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11A, MRE11B

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


产品信息

67570-1-PBS targets MRE11A in WB, Indirect ELISA applications and shows reactivity with Human, Mouse, Rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Mouse, Rat
免疫原 MRE11A fusion protein Ag28847 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
别名 ATLD, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11A, MRE11B
观测分子量 81 kDa
GenBank蛋白编号BC063458
基因名称 MRE11A
Gene ID (NCBI) 4361
RRIDAB_2882784
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP49959
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Mre11 (meiotic recombination 11), also named as Mre11A, is a component of the MRN( MRE11/RAD50/NBS1) complex which is a versatile complex, playing a key role in the sensing, processing, and repair of DSBs. MRE11 possesses both endonuclease and 3'-5' exonuclease activity. It contains two DNA-binding domains (DBDs), enabling it to bind both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with CtIP (CtBP [C terminal binding protein] interacting protein) to initiate end resection. It's reported that MRE11 is over-expressed in breast cancers. (PMID:38128537; 22914783)

Loading...