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  • Featured Product
  • KD/KO Validated

MTMR2 Monoclonal antibody, PBS Only

MTMR2 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1B11B7

Cat No : 67312-1-PBS

Print datasheet

Synonyms

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

验证数据展示

  • WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

  • WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB analysis of HeLa using 67312-1-Ig (same clone as 67312-1-PBS)

    WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells. This data was developed using the same antibody clone with 67312-1-PBS in a different storage buffer formulation.

产品信息

67312-1-PBS targets MTMR2 in WB, Indirect ELISA applications and shows reactivity with Human, Pig samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, Pig
Immunogen MTMR2 fusion protein Ag28413 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name myotubularin related protein 2
Synonyms CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 66-73 kDa
GenBank Accession NumberBC052990
Gene Symbol MTMR2
Gene ID (NCBI) 8898
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ13614
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.