MeCP2 phospho Ser80 antibody (pAb)

Host / Isotype

Rabbit / Serum

Reactivity

Human, Rat

Applications

WB

Cat No : 39733,39734 39733

Synonyms

MECP2, cpg methylation, dna methylation, ser80, serine 80, phospho-serine 80, rett syndrome, autism, sample



产品信息

Tested Applications WB

Applications Validated by Active Motif: WB: 1:2,000 - 1:10,000 dilution

Tested Reactivity Human, Rat
Host / Isotype Rabbit / Serum
Class Polyclonal
Type Antibody
ModificationPhosphorylated
Immunogen This MeCP2 phospho Ser80 antibody was raised against a peptide containing phospho Ser80 of mouse MeCP2.
Full Name MeCP2 phospho Ser80 antibody (pAb)
Synonyms MECP2, cpg methylation, dna methylation, ser80, serine 80, phospho-serine 80, rett syndrome, autism, sample
Molecular weight 70 kDa
GenBank accession numberNP_001075448
RRIDAB_2793324
Purification Method None
Buffer Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MeCP2 (methyl-CpG binding protein 2)can repress transcription by recruiting the Sin3 complex including histone deacetylases (HDACs). MeCP2 is distributed throughout the nucleus in human cells. Phosphorylation of MeCP2 at serine 80 may regulate the activity of neurons switching between resting and active states in neural circuits.