验证数据展示
产品信息
83934-2-PBS targets NEU2 in IF/ICC, FC (Intra), ELISA applications and shows reactivity with human, rat samples.
经测试应用 | IF/ICC, FC (Intra), ELISA Application Description |
经测试反应性 | human, rat |
免疫原 | NEU2 fusion protein Ag17386 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | sialidase 2 (cytosolic sialidase) |
别名 | SIAL2, N-acetyl-alpha-neuraminidase 2, N acetyl alpha neuraminidase 2, EC:3.2.1.18, Cytosolic sialidase |
计算分子量 | 380 aa, 42 kDa |
GenBank蛋白编号 | BC107053 |
基因名称 | NEU2 |
Gene ID (NCBI) | 4759 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | Q9Y3R4 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
NEU2, also named as Sialidase 2, neuraminidase 2, catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. NEU2 is localized in the cytosol and plasma membrane and takes part in myoblast and neuronal differentiation. It is almost undetectable under normal physiological conditions, and was found to be involved into apoptotic events in pancreatic ductal adenocarcinoma, one of the most dangerous cancers due to poor diagnosis and prognosis. (PMID: 30439363)