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Species Reactivity
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验证数据展示

  • IF Staining of PC-12 using 83934-2-RR (same clone as 83934-2-PBS)

    IF Staining of PC-12 using 83934-2-RR (same clone as 83934-2-PBS)

    Immunofluorescent analysis of (4% PFA) fixed PC-12 cells using NEU2 antibody (83934-2-RR, Clone: 240685C12 ) at dilution of 1:250 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 83934-2-PBS in a different storage buffer formulation.

  • FC experiment of A549 using 83934-2-RR (same clone as 83934-2-PBS)

    FC experiment of A549 using 83934-2-RR (same clone as 83934-2-PBS)

    1x10^6 A549 cells were intracellularly stained with 0.25 ug Neu2 Recombinant Antibody (83934-2-RR, Clone:240685C12) and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 83934-2-PBS in a different storage buffer formulation.

NEU2 Recombinant antibody, PBS Only

NEU2 Uni-rAbTM Recombinant Antibody for IF/ICC, FC (Intra), ELISA
Cat No. 83934-2-PBS

Print datasheet

CloneNo. 240685C12

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

IF/ICC, FC (Intra), ELISA

Synonyms

SIAL2, N-acetyl-alpha-neuraminidase 2, N acetyl alpha neuraminidase 2, EC:3.2.1.18, Cytosolic sialidase

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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产品信息

83934-2-PBS targets NEU2 in IF/ICC, FC (Intra), ELISA applications and shows reactivity with human, rat samples.

Tested Applications IF/ICC, FC (Intra), ELISA Application Description
Tested Reactivity human, rat
Immunogen NEU2 fusion protein Ag17386 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name sialidase 2 (cytosolic sialidase)
Synonyms SIAL2, N-acetyl-alpha-neuraminidase 2, N acetyl alpha neuraminidase 2, EC:3.2.1.18, Cytosolic sialidase
Calculated Molecular Weight 380 aa, 42 kDa
GenBank Accession NumberBC107053
Gene Symbol NEU2
Gene ID (NCBI) 4759
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ9Y3R4
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NEU2, also named as Sialidase 2, neuraminidase 2, catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. NEU2 is localized in the cytosol and plasma membrane and takes part in myoblast and neuronal differentiation. It is almost undetectable under normal physiological conditions, and was found to be involved into apoptotic events in pancreatic ductal adenocarcinoma, one of the most dangerous cancers due to poor diagnosis and prognosis. (PMID: 30439363)