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验证数据展示

  • IF Staining of mouse brain using CL488-67717

    IF Staining of mouse brain using CL488-67717

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse brain tissue using CoraLite® Plus 488 NMDAR1/GRIN1 antibody (CL488-67717, Clone: 1H2C2 ) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CoraLite® Plus 488-conjugated NMDAR1/GRIN1 Monoclonal antibody

NMDAR1/GRIN1 Monoclonal Antibody for IF-P
Cat No. CL488-67717

产品说明书

CloneNo. 1H2C2

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat, rabbit, chicken

应用

IF-P

别名

GRIN1, NMDAR1, NMDAR 1, Glutamate receptor ionotropic, NMDA 1, GluN1

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  CoraLite® Plus 488
规格: 

-/ -

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经过测试的应用

Positive IF-P detected inmouse brain tissue
For other applications, we recommend the unconjugated version of this antibody, 67717-1-Ig

推荐稀释比

应用推荐稀释比
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-67717 targets NMDAR1/GRIN1 in IF-P applications and shows reactivity with human, mouse, rat, rabbit, chicken samples.

经测试应用 IF-P Application Description
经测试反应性 human, mouse, rat, rabbit, chicken
免疫原 NMDAR1/GRIN1 fusion protein Ag26364 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 glutamate receptor, ionotropic, N-methyl D-aspartate 1
别名 GRIN1, NMDAR1, NMDAR 1, Glutamate receptor ionotropic, NMDA 1, GluN1
计算分子量 105 kDa
观测分子量105-120 kDa
GenBank蛋白编号NM_000832
基因名称 NMDAR1
Gene ID (NCBI) 2902
RRIDAB_3672960
偶联类型 CoraLite® Plus 488 Fluorescent Dye
最大激发/发射波长493 nm / 522 nm
形式 Liquid
纯化方式Protein G purification
储存缓冲液 PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
储存条件Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

GRIN1 encodes subunit 1 of the N-methyl-D-aspartate (NMDA) receptor, which is a heteromeric glutamate-gated calcium ion channel essential for synaptic function in the brain (PMID: 25864721, PMID: 25864721). NMDARs play important roles in normal brain development and function, such as synaptic plasticity, neural development, learning and memory (PMID: 20716669). NMDAR dysfunction has been associated with several neurological disorders including Parkinson, Alzheimer and Huntington diseases. Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum (PMID: 17015831).

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 NMDAR1/GRIN1 antibody CL488-67717Download protocol
Standard Protocols
Click here to view our Standard Protocols