NOX1 Recombinant antibody, PBS Only
NOX1 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
241935E7
验证数据展示
产品信息
The immunogen of 84700-1-PBS is NOX1 Fusion Protein expressed in E. coli.
| Tested Applications | WB, Indirect ELISA Application Description |
| Tested Reactivity | human, mouse |
| Immunogen | NOX1 fusion protein Ag12187 种属同源性预测 |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Full Name | NADPH oxidase 1 |
| Synonyms | MOX1, MOX 1, Mitogenic oxidase 1, GP91 2, EC:1.6.3.- |
| Calculated Molecular Weight | 564 aa, 65 kDa |
| Observed Molecular Weight | 59 kDa |
| GenBank Accession Number | BC075014 |
| Gene Symbol | NOX1 |
| Gene ID (NCBI) | 27035 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q9Y5S8 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
NNOX1(NADPH oxidase 1) is also named as MOX1, NOH1 and belongs to the reactive oxygen species (ROS)-generating NADPH oxidase family. It plays a role in host defense, cell growth and differentiation, cell migration, and malignant transformation(PMID:20351171). It also can mediate oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1(PMID:18454179). It has 3 isoforms produced by alternative splicing with the molecular weight of 65 kDa, 22 kDa and 59 kDa. The full length protein has two glycosylation sites. It always can be detected two bands of 63 kDa and 55 kDa in cells by western blot or another lower band of 45 kDa which is not likely due to alternative translation or splice variation, but as adjustment for the signal peptide and tag removal(PMID:17560373) or unspecifc(PMID:17460729).