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NPTX2 Monoclonal antibody, PBS Only

NPTX2 Monoclonal Antibody for WB,Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, pig, rabbit

Applications

WB,Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H8D8

Cat No : 68709-1-PBS

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Synonyms

NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2

验证数据展示

  • WB analysis using 68709-1-Ig (same clone as 68709-1-PBS)

    WB analysis using 68709-1-Ig (same clone as 68709-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68709-1-Ig (NPTX2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68709-1-PBS in a different storage buffer formulation.

产品信息

68709-1-PBS targets NPTX2 in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig, rabbit samples.

Tested Applications WB,Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat, pig, rabbit
Immunogen NPTX2 fusion protein Ag33808 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name neuronal pentraxin II
Synonyms NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2
Calculated Molecular Weight 47 kDa
Observed Molecular Weight50-55 kDa
GenBank Accession NumberBC009924
Gene Symbol NPTX2
Gene ID (NCBI) 4885
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP47972
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Neuronal pentraxins constitute a family of proteins that are homologous to C-reactive protein (CRP) and serum amyloid P component (SAP), including NPTX1, NPTX2, and the neuronal pentraxin receptor (NPTXR). NPTX2, also known as NARP (neuronal activity-regulated pentaxin), is a secreted protein involved in excitatory synapse formation. It also plays a role in the clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. NPTX2 is highly up-regulated in Parkinson's disease (PD), suggesting it may be involved in the pathology of PD. (PMID: 12895424; 17987278; 10748068)