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验证数据展示

  • WB analysis of pig brain using 66997-1-Ig (same clone as 66997-1-PBS)

    WB analysis of pig brain using 66997-1-Ig (same clone as 66997-1-PBS)

    pig brain tissue were subjected to SDS PAGE followed by western blot with 66997-1-Ig (SERPINI1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66997-1-PBS in a different storage buffer formulation.

  • IHC staining of rat cerebellum using 66997-1-Ig (same clone as 66997-1-PBS)

    IHC staining of rat cerebellum using 66997-1-Ig (same clone as 66997-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat cerebellum tissue slide using 66997-1-Ig (Neuroserpin antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66997-1-PBS in a different storage buffer formulation.

  • IHC staining of rat cerebellum using 66997-1-Ig (same clone as 66997-1-PBS)

    IHC staining of rat cerebellum using 66997-1-Ig (same clone as 66997-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat cerebellum tissue slide using 66997-1-Ig (Neuroserpin antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66997-1-PBS in a different storage buffer formulation.

  • IF Staining of U-251 using 66997-1-Ig (same clone as 66997-1-PBS)

    IF Staining of U-251 using 66997-1-Ig (same clone as 66997-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed U-251 cells using Neuroserpin antibody (66997-1-Ig, Clone: 1G4C6 ) at dilution of 1:2000 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66997-1-PBS in a different storage buffer formulation.

Neuroserpin Monoclonal antibody, PBS Only

Neuroserpin Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 66997-1-PBS

产品说明书

CloneNo. 1G4C6

宿主/亚型

Mouse / IgG1

种属反应性

Human, pig, rat

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

DKFZp781N13156, neuroserpin, Peptidase inhibitor 12, PI 12, PI12, Serpin I1, SERPINI1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66997-1-PBS targets Neuroserpin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, pig, rat samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 Human, pig, rat
免疫原 Neuroserpin fusion protein Ag28636 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 serpin peptidase inhibitor, clade I (neuroserpin), member 1
别名 DKFZp781N13156, neuroserpin, Peptidase inhibitor 12, PI 12, PI12, Serpin I1, SERPINI1
计算分子量 410 aa, 47 kDa
观测分子量 46 kDa
GenBank蛋白编号BC018043
基因名称 Neuroserpin
Gene ID (NCBI) 5274
RRIDAB_2882314
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDQ99574
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.