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OPA1 Monoclonal antibody, PBS Only

OPA1 Monoclonal Antibody for WB, IHC, ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, mouse, pig, rat

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

CloneNo.

1B2D8

Cat no : 66583-1-PBS

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Synonyms

FLJ12460, KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1



产品信息

66583-1-PBS targets OPA1 in WB, IHC, ELISA applications and shows reactivity with Human, mouse, pig, rat samples.

Tested Applications WB, IHC, ELISA Application Description
Tested Reactivity Human, mouse, pig, rat
Immunogen OPA1 fusion protein Ag26868 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name optic atrophy 1 (autosomal dominant)
Synonyms FLJ12460, KIAA0567, largeG, MGM1, NTG, OPA1, Optic atrophy protein 1
Calculated Molecular Weight 960 aa, 112 kDa
Observed Molecular Weight 100 kDa and 80-90 kDa
GenBank Accession NumberBC075805
Gene Symbol OPA1
Gene ID (NCBI) 4976
RRIDAB_2881943
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO60313
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

OPA1 is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. OPA1 localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics. Mutation of OPA1 causes the disease dominant optic atrophy, a degeneration of the retinal ganglion cells. OPA1 undergoes complex posttranscriptional regulation and posttranslational proteolysis. OPA1 is regulated by proteolytic cleavage, which degrades long OPA1 isoforms into short isoforms. The gene OPA1 can be cleaved into some chains with MW 100 kDa and 80-90 kDa.